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[16] [18] Healthcare providers should weigh the anticipated benefits against potential risks and consider alternative routes or lower doses when appropriate

And looking at exercise in particular and through the lens of recovery, I mean, what happens, right, we're damaging muscle, we're raising blood pressure, we're raising heart rate, it increases free radical damage, it increases inflammatory markers, it increases cortisol

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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element